Volume : IV, Issue : III, March - 2014


Cariappa Kb, Venkatesh G

Abstract :

 Background: Metabolic syndrome (MetS) refers to a cluster of features conferring the risk for cardiovascular disease and type 2 diabetes mellitus. Considering the fact that the thyroid dysfunction is also associated with the risk for CVD, this study was undertaken to estimate the levels of thyrotropin stimulating hormone (TSH) in subjects with and without metabolic syndrome. Materials and Methods: The study population included 50 subjects with metabolic syndrome and 50 subjects without metabolic syndrome. Blood pressure and anthropometric measurements were measured in all the study subjects, following which a fasting blood sample was obtained for the estimation of fasting blood sugar (FBS), lipid profile and TSH. The data obtained was analyzed using SPSS software. AHA/NHLBI definition was used to define MetS. The values obtained were compared using student t test and correlated using Pearson correlation. Results: TSH levels were high among the subjects with MetS and it was statistically highly significant (<0.01). Pearson‘s product–moment correlation of TSH with age and the components of the MetS yielded a positive and highly significant (<0.01) correlation with age, FBS and waist circumference (WC). It also significantly correlated with triglyceride (TGL) (<0.05). The prevalence of hypothyroidism in MetS was 46% and the hyperthyroidism was 6%. Conclusion: High TSH was found to be associated with metabolic syndrome, suggesting that hypothyroid subjects are prone for cardiometaboilc risk

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Cariappa KB, Dr. Venkatesh G. “STUDY OF TSH LEVELS IN SUBJECTS WITH AND WITHOUT METABOLIC SYNDROME” Indian Journal of Applied Research, Vol.IV, Issue. III

Number of Downloads : 725

References :

1. Prasad H, Ryan DA, Celzo MF, Stapleton D. Metabolic syndrome: definition and therapeutic implications. Postgrad Med. 2012; 124(1):21–30. 2. Papazafiropoulou A. Prevalence of thyroid dysfunction among Greek Type 2 diabetic patients attending an outpatient clinic. Journal of Clinical Medicine Research 2010; 2 :75–78 3. Iervasi G, Nicolini G. Thyroid hormone and cardiovascular system: from basic concepts to clinical application. Intern Emerg Med. 2013; 8 Suppl 1:S71–4. 4. Kanjilal S, Shanker J, Rao VS, Khadrinarasimhaih NB, Mukherjee M, Iyengar SS, Kakkar VV. Prevalence and component analysis of metabolic syndrome: An Indian atherosclerosis research study perspective. Vascular Health and Risk Management 2008:4(1) 189–197. 5. Chen HS, Wu TE, Jap TS, Lu RA, Wang ML, Chen RL, Lin HD. Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients. Diabet Med 2007 ;24:1336–44 6. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ,Smith SC Jr, Spertus JA, Costa F; American Heart Association; National Heart, Lung, and Blood Institute (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung and Blood Institute Scientific Statement. Circulation 112: 2735–2752 7. Perros P, McCrimmon RJ, Shaw G, Frier BM. Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabetic Medicine 1995; 12: 622– 627 8. Uzunlulu M, Yorulmaz E, Oguz A. Prevalence of subclinical hypothyroidism in patients with metabolic syndrome. Endocr J. 2007; 54(1):71–6. 9. Chugh K, Goyal S, Shankar V, Chugh SN. Thyroid function tests in metabolic syndrome. Indian journal of endocrinology and metabolism 2012, 16(6), 958. 10. Kota SK, Meher LK, Krishna SVS, Modi KD. Hypothyroidism in metabolic syndrome. Indian journal of endocrinology and metabolism 2012, 16 (Suppl 2), S332