Study on Serum Calcium levels in subclinical hypothyroidism among patients attending Jorhat Medical College:A hospital based study

Dr.Reetwik Kumar Dutta; Dr.Saurabh Borkotoki

Volume : VII, Issue : IV, April - 2017

Study on Serum Calcium levels in subclinical hypothyroidism among patients attending Jorhat Medical College:A hospital based study

Dr. Reetwik Kumar Dutta, Dr. Saurabh Borkotoki

Abstract :

Introduction: Thyroid stimulating hormone (TSH) of the anterior pituitary controls synthesis and secretion of thyroid hormones– thyroxine (T4) and triiodothyronine(T3) .Thyroid hormone stimulates almost all aspects of bio–molecular metabolism, affects basal metabolic rate and plays critical roles in maintaining metabolic homeostasis . Thus thyroid dysfunction seems to be associated with derranged mineral metabolism. Subclinical hypothyroidism is a condition in which TSH is elevated indicating lowered thyroid activity, but free T4 is normal. Assam belongs to the sub Himalayan Goiter belt, thus a prevalent region of thyroid dysfunction and therefore, by estimating serum calcium in cases of high TSH with no clinical symptoms, the study attempts to evaluate the findings critically.

Aims and Objective:

· To determine serum Calcium in subclinical hypothyroid cases

· To analyse the values of serum Calcium and compare the findings with other studies

Materials and methods:

Type of study: case control study (40 cases and 40 controls).

Place of Study–Department of Biochemistry, Jorhat Medical College Hospital

Laboratory investigations:

· Serum calcium – estimated in Vitros 250 dry chemistry autoanalyser

· Serum TSH, T3 and T4 – estimated in Access Immuno Assay Systems (Beckman Coulter)

Statistical analysis: Statistical analysis and significance was carried out using Microsoft Excel and online calculator.

Results: Mean values of TSH, Serum calcium cases was 11.65±1.35(µIU/mL ) and 7.13±0.36 (mg/dL ) in cases of subclinical hypothyroidism.Serum calcium showed a negative (r = –0.645) Pearson coefficient value with serum TSH in the cases.

Conclusion: Serum calcium decreases with increase in the amount of TSH ,thus implies weightage of routine serum calcium estimation in a thyroid dysfunction patient.