Synthesis, Spectral, Electrochemical Analysis and Screening for α–Glucosidase Inhibition of Some Complexes of Copper (II) with Amino acids

Prof. I. P. Tripathi; Aarti Kamal; Mahendra Kumar Mishra; Atul Dwivedi; Ruchita Tripathi; Chinmayi Mishra; Laxmi Kant Shastri

Volume : IV, Issue : V, May - 2014

Synthesis, Spectral, Electrochemical Analysis and Screening for α–Glucosidase Inhibition of Some Complexes of Copper (II) with Amino acids

Prof. I. P. Tripathi, Aarti Kamal, Mahendra Kumar Mishra, Atul Dwivedi, Ruchita Tripathi, Chinmayi Mishra, Laxmi Kant Shastri

Abstract :

Complexes of some metal ions with amino acids can be used as models to study the pharmaco–dynamic effects of drugs or for increasing the biocompatibility and minimize toxic effects of some metal ions. Interac –tions between transitional metal ions and amino acids are very interesting in the biological applications. A series of complexes of Cu(II) and amino acid (L), ie. glycine, valine, asparginine and arginine with formula [Cu(L)2]+2 have been synthesized and characterized as mononuclear species on the basis of elemental chemical analysis, infrared spectra, UV–Visisble and cyclicvoltametery measurements. The IR spectra indicated the presence of amino acid coordinated through nitrogen atom and the oxygen from the carboxylic group. The experimental data suggest that the ligands act as bidentate and adopt an octahedral stereochemistry. In this study, we have also focused on the inhibitory activity of these metal complexes on α –glucosidase.