Treatment results of carboplatin based concurrent chemoradiation for locally advanced cervical carcinoma.

Dr Suresh Kumar Thakur; Dr S K Azad

Volume : VIII, Issue : VIII, August - 2018

Treatment results of carboplatin based concurrent chemoradiation for locally advanced cervical carcinoma.

Dr Suresh Kumar Thakur, Dr S K Azad

Abstract :

Background: Carcinoma of cervix is the most common malignancy of women at our center and the majority of cases present locally advanced stages. The aim of this study was to assess the efficacy and toxicity of carboplatin based concurrent chemoradiation in patients with locally advanced cervical carcinoma. Methods: Fifty seven locally advanced cervical cancer patients were enrolled in this study and fifty eligible patients were received weekly carboplatin at dose of area under curve 2, along with radical radiotherapy. The total dose of 50 Gy in 25 fractions over a period of 5 weeks was given during external beam radiotherapy and 19.5 Gy (6.5 Gy per fraction/week) was given during high dose rate achytherapy. Results: After two months of completion of treatment the complete response rate was observed in 37(74%) patients, with 11 (22%) patients had partial response and 02 (04%) patients had stable disease or no response to treatment. The hematological toxicities with grade III were observed in 06(12%) patients and grade IV observed in 02(04%) patients. Conclusion: Despite initial promising results with acceptable toxicities, further large randomized study is needed to judge the efficacy of carboplatin along with radical radiotherapy in cervical cancer patients.