UTILITY OF SERUM CHOLINESTERASE AS PREDICTOR OF CLINICAL OUTCOME IN ORGANOPHOSPHORUS AND ORGANOCARBAMATE POISONING

Padmaja Mekala; Shobha Jagdish Chandra U

Volume : VI, Issue : IX, September - 2016

UTILITY OF SERUM CHOLINESTERASE AS PREDICTOR OF CLINICAL OUTCOME IN ORGANOPHOSPHORUS AND ORGANOCARBAMATE POISONING

Padmaja Mekala, Shobha Jagdish Chandra U

Abstract :

Poisoning is a common method of suicide. Organophosphorous and organocarbamate compounds are commonly used pesticides in agriculture. These are potent cholinesterase inhibitors. Estimation of Serum cholinesterase (SchE) is simpler and accurate than estimation of RBC cholinesterase. SchE seems recover far more rapidly than RBC cholinesterase. In inpatient case records clinical status, ventilator requirements and SchE levels at admission, 24, 72,120 hrs and at discharge were collected and analysed. SchE levels determined by measuring the rate of hydrolysis of substrate catalysed by SchE using UV– Spectrophotometry. In survivors, SChE recovery was statistically significant for admission – 24 h, admission – 72 h, 24 –72 h, 24 – 120 h and admission –120 h (p < 0.001). Increasing trend observed in serial SchE levels during recovery phase. SchE levels increased in cases of OP and OC poisoning who survived . Estimation of SchE levels may be a useful predictor of clinical outcome.