Whether combinedly administered Tranexamic Acid in TKR is more effective than only intravenous administration ?

Dr. Satyen Joshi; Dr. Brijbhushan Mahajan; Dr. Nitish Agrawal; Dr. Bhalchandra Bhalerao

Volume : VIII, Issue : III, March - 2018

Whether combinedly administered Tranexamic Acid in TKR is more effective than only intravenous administration ?

Dr. Satyen Joshi, Dr. Brijbhushan Mahajan, Dr. Nitish Agrawal, Dr. Bhalchandra Bhalerao

Abstract :

Introduction: The aim of our study is to compare efficacy of 3 doses of intravenous (IV) Tranexamic acid (TXA) versus combined IV and intraarticular TXA in reducing blood loss and transfusion requirement in patients who underwent primary total knee arthroplasty. Methods: Group A patients were administered 3 IV doses of TXA. Group B patients were administered 1 gram of IV and 2 grams of IA dose. Results: The mean 48 hrs drain collection was 238.33 ml in group A and 149 ml in group B. Mean hemoglobin drop is 2.39 gm% in group A and 1.74 gm% in group B. Post operative blood transfusion was required in 12 patients (40%) of group A and 5 patients (16.67%) of group B. Conclusion: IA with IV TXA is more beneficial than IV TXA in reducing blood loss in primary total knee arthroplasty.