Propofol and fentanyl are the commonly used drugs for induction of general anaesthesia. Propofol when given alone does not cause much changes in hemodynamic status in healthy (ASA grade1) individuals. When it is given in combination with fentanyl it causes detrimental effects in patients especially compromised patients like hypotension and other cardio respiratory disturbances. These hazardous and fatal effects can be reduced and eliminated by preloading the patients with colloid solutions .We studied a group of 60 patients of our hospital undergoing surgery without preload with colloids then with preloads Patients were operated under general anaesthesia induced with propofol and fentanyl. We concluded that fluid preload is beneficial to counter the harmful effects of propofol and fentanyl combination