Volume : III, Issue : XII, December - 2014

A Case Report: Malignant Infantile Osteopetrosis (MIOP)

Dr. Nikhil Verma, Dr. Neelam Raval

Abstract :

Background: Malignant infantile osteopetrosis (MIOP) presents early in life with extreme sclerosis of the skeleton and reduction of bone marrow spaces. Since there is a defect in the bone marrow, the disease can cause anaemia, extra medullary haematopoiesis secondary to anaemia leading to hepatosplenomegaly, cranial nerves compression and severe growth failure. This disorder is often lethal within the first decade of life because of secondary infections. Stem cell transplantation (SCT) remains the only curative therapy. Case Presentation: We report a 4-month old male infant, diagnosed as MIOP while investigating the cause of hepatosplenomegaly. Conclusion: Malignant infantile osteopetrosis should be kept in mind as a rare cause of hepatosplenomegaly and the patient should be referred for stem cell transplantation before neurologic or visual impairment develops.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Nikhil Verma,Dr.Neelam Raval A Case Report: Malignant Infantile Osteopetrosis (Miop) International Journal of Scientific Research, Vol : 3, Issue : 12 December 2014

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