A Comparative study of Thoracic epidural  Clonidine hydrochloride and IV Fentanyl  hydrochloride + IV Lignocaine hydrochloride to  attenuate hemodynamic response induced by  endobronchial intubation

DR. Dipika Patel; DR. Yatrik Ganatra; DR. Neeta Gosai; DR. Bijal Shah; DR.Rashmi Anand; DR. Bipin Patel

Volume : III, Issue : II, February - 2014

A Comparative study of Thoracic epidural Clonidine hydrochloride and IV Fentanyl hydrochloride + IV Lignocaine hydrochloride to attenuate hemodynamic response induced by endobronchial intubation

Dr. Dipika Patel, Dr. Yatrik Ganatra, Dr. Neeta Gosai, Dr. Bijal Shah, Dr. Rashmi Anand, Dr. Bipin Patel

Abstract :

Objective:To compare the effect of Thoracic epidural Clonidine hydrochloride and IV Fentanyl citrate + IV Lignocaine hydrochloride to attenute hemodynamic response to endoonchial intubation in thoracotomy. Method: 60 patients with ASA– I & II with age group 20 to 65yrs scheduled for elective thoracotomies were randomly allocated in two groups.General anesthesia was provided with endoonchial intubation.Group A :Clonidine 3mcg/kg diluted with 10ml saline given as epidural bolus 20 minutes before induction. Group B:10ml of NS as epidural bolus 20 min before induction & Iv fentanyl citrate(2 mcg/kg) and lignocaine hydrochloride(2 mg/kg) during induction.Haemodynamic variables were continuously recorded. Results: After Induction, In group A,decrease in Mean BP and HR from baseline were statasticaly significant compared to group B.After Endoonchial intubation,haemodynamic change in Group A showed very less haemodynamic variation as compared to Group B.(P