A study of Non–fermenting Gram negative bacilli with special reference to MBL production in a rural tertiary care hospital.

Dr. Santosh Tathe; Dr. Rajesh Ovhal; Dr. Sandeep Nilekar

Volume : V, Issue : IV, April - 2016

A study of Non–fermenting Gram negative bacilli with special reference to MBL production in a rural tertiary care hospital.

Dr. Santosh Tathe, Dr. Rajesh Ovhal, Dr. Sandeep Nilekar

Abstract :

Background: The most active β–lactams, namely carbapenems are mainstay of treatment for serious infections. Acquired metallo–β–lactamases (MBL) in Non–fermenters have recently emerged as one of the most worrisome resistance mechanisms with capacity to hydrolyze all β–lactams, including carbapenems & also other group of antibiotics & ability to transfer it to other bacteria via plasmids or tansposones. We conducted this study to find the prevalence of MBL–producing non– fermenting bacilli & their comparative antibiogram. Materials and Methods: The study was conducted over a period of 24 months in a tertiary rural hospital. Isolates were screened for meropenem resistance by conventional methods & were confirmation of MBL by ‘Double Disk Synergy Test‘ (DDST), ‘Disc Potentiation Test‘ (DPT) and ‘E–Test‘. Results: Our findings show that isolates having MBL production also have high degree of multidrug resistance compaired to MBL non producers. Active surveillance to detect MBL producers is the need of time.