Volume : III, Issue : X, October - 2014

Comparative Efficacy And Safety Of Doxofylline Versus Theophylline in Bronchial Asthma And Copd Patients

Dr. Rupali Bajrang Jadhav, Dr. Mirza Shiraz Baig, Dr. Prakashchandra Rambhau Gade, Dr. Prakash Narayan Khandelwal

Abstract :

The present study was conducted in the department of pharmacology at government medical college and hospital , Aurangabad to compare the efficacy and safety of doxofylline versus theophylline in the form of sustained release tablets in mild to morderate asthma and COPD patients. It was a randomized open label phase 3 clinical trial including men and women above 18 years of age attending medicine opd.The investigations carried out at start were lung function tests ie FEV1 , FVC, FEF, PEFR and ratio of FEV1/ FVC, they were repeated after 1 month of study period when patients were given theophylline and doxofylline after randomization in two groups.At the end it was found that FEV1, FEF and PEFR was significantly improved in doxofylline group than theophylline group . Considering the results obtained in the present study ,doxofylline seems to be a better alternative to theophylline in maintenance therapy for onchial asthma and COPD.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Rupali Bajrang Jadhav, Dr. Mirza Shiraz Baig, Dr. Prakashchandra Rambhau Gade, Dr. Prakash Narayan khandelwal Comparative Efficacy And Safety Of Doxofylline Versus Theophylline in Bronchial Asthma And Copd Patients International Journal of Scientific Research, Vol : 3, Issue : 10 October 2014

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