COMPARATIVE STUDY OF TWO ARBs ON MEMORY AND PSYCHOMOTOR FUNCTIONS IN MILD TO MODERATE HYPERTENSION

Kavita Rathore; Dr. Sunil Kumar Mathur

Volume : V, Issue : IX, September - 2016

COMPARATIVE STUDY OF TWO ARBs ON MEMORY AND PSYCHOMOTOR FUNCTIONS IN MILD TO MODERATE HYPERTENSION

Kavita Rathore, Dr. Sunil Kumar Mathur

Abstract :

In this study we evaluated the effects of two ARBs, Telmisartan and Olmesartan on memory and psychomotor functions in Indian population. Material and Methods : A Prospective, comparative, randomized, before–after, open–label study was conducted at a tertiary care hospital of Ajmer. Memory functions were evaluated with PGI Memory Scale, while psychomotor functions were evaluated with Six Letter Cancellation test and Digit Letter Substitution test. Total 101 patients (SBP≥ 140 mm hg; DBP ≥ 90 mm Hg), Group I (n=52) received Telmisartan 40 mg OD and group II (n=49) received Olmesartan 20 mg OD for 16 weeks. Wilcoxon Signed Rank test and Mann Whitney U test were used. Statistical significance was considered at P<0.05. Results : A improvement in scores of memory and psychomotor functions were observed in both the groups. A statistically significant improvement (p<0.05) was shown in 3 subtests out of 10 subtests of cognitive fuctions in telmisartan as compare to Olmesartan. Both the drugs showed significant improvement in psychomotor function tests (P<0.05). Conclusion : Telmisartan showed more improvement as compare to Olmesartan.