Diagnostic and prognostic significance of urinary xanthurenic acid excretion in tuberculosis

Dr.V.K.Srivastava; Dr. Mohd Arif Siddiqui

Volume : V, Issue : V, May - 2016

Diagnostic and prognostic significance of urinary xanthurenic acid excretion in tuberculosis

Dr. V. K. Srivastava, Dr. Mohd Arif Siddiqui

Abstract :

Objective: To assess the diagnostic and prognostic significance of the test in tuberculous patients. Methods: Xanthurenic acid excretion in urine was measured before and after an oral load of 5 gm tryptophan in 10 healthy individuals and 24 patients of tuberculosis (pulmonary, lymph glandular and osteocarticular). Xanthurenic acid excretion estimation was done again after 3 months of successful antituberculosis chemotherapy in pulmonary tuberculosis cases only. Results: The mean excretion values before and after load in the tuberculosis patients were found higher as compared to control subjects. These values came down significantly after successful chemotherapy of 3 months. Conclusion: We found that altered tryptophan metabolic pathway did operate in tuberculosis patients, being maximum in pulmonary followed by lymph gland and osteo–articular tuberculosis respectively