Diagnostic Utility of Fibrinogen Estimation by Clauss & Pt Derived Method in an Oncology Setup

Dr. Ritu Garg; Dr Jyoti Sawhney; Dr. Dhaval Jetly; Dr. M.J.Shah

Volume : III, Issue : VI, June - 2014

Diagnostic Utility of Fibrinogen Estimation by Clauss & Pt Derived Method in an Oncology Setup

Dr. Ritu Garg, Dr Jyoti Sawhney, Dr. Dhaval Jetly, Dr. M. J. Shah

Abstract :

Aim: Fiinogen assay is significant in area of thrombosis research since it is affected by various physiological & pathological conditions such inherited/acquired coagulopathies indicated by low levels of fiinogen whereas increased levels is a strong independent factor for development of arterial thromboembolism. We compare PT derived method & clauss method of quantitative fiinogen estimation in 2 groups of patients. Group 1:with Normal coagulation parameters and liver function tests and Group 2:With Deranged coagulation parameters &/or liver function tests. Materials & methods: Reagents for quantitative fiinogen determination on human citrated plasma using IL coagulation system based on absorbance changes at 450 nm during clotting process of PT were used.Normal range of fiinogen levels were determined from samples of 20 healthy subjects. Sample size of 64 patients is considered out of whom 15 are cases of solid malignancy, 45 of heamatological malignancy( 20 of which are APML) & 4 patients are on oral anticoagulants. They are segregated in 2 groups based on their coagulation parameters & LFT�s. Result: In patients with normal coagulation profile ie group 1 ,clauss method was not statistically significant (p value >0.05) whereas In patients with deranged coagulation profile ie group 2, clauss method was statistically significant (p value <0.05). Conclusion: Clauss method is preferred in oncology patients for quantitative fiinogen estimation as compared to PT derived method.