Volume : III, Issue : II, February - 2014

Hemophagocytic Lymphohistiocytosis – Revisited

Dr. Maganlal Jain, Dr. Arundhati Diwan, Dr. Rahul Shewale

Abstract :

Hemophagocytic lymphohistiocytosis is a potentially life threatening condition characterized by aggressive proliferation of macrophages and T lymphocytes leading to haemophagocytosis of other blood cells and multi organ failure. It can be primary or genetic & secondary or reactive. Secondary form commonly occurs in adult population in the setting of infections, malignancies, autoimmune diseases & drugs. The immune response leads to hypersecretion of proinflammatory cytokines. Diagnosis is based on the criteria laid down by the Histiocytic Society in 2004. Raised serum ferritin level is an important laboratory hallmark for diagnosis. Corticosteroids, cyclosporine, etoposide can be used in the treatment. Macrophage activation syndrome if left untreated has been associated with rapidly fatal outcome hence high index of suspicion is needed among the physicians.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Maganlal Jain, Dr. Arundhati Diwan, Dr. Rahul Shewale Hemophagocytic Lymphohistiocytosis‾Revisited International Journal of Scientific Research, Vol.III, Issue.II February 2014

Number of Downloads : 1258

References :