Volume : IV, Issue : VIII, August - 2015

Neurohistological Effects of Lead on Corpus Striatum of Adult Albimo Rat

Dr S M Dawar Husain

Abstract :

LEAD is toxic to every organ of body, including central nervous system. This study is aimed to observe the histopathological changes in the corpus striatum of rat induced by oral administration of lead compound in adult albino rats. Total number of 20 adult albino rats of either sex were included in this study, consisting of equal numbers in both control and experimental groups. Experimental group received 4% aquous lead acetate orally for 15 days., then animals of both groups were anaesthetized with ether and perfused with 10% formalin. Corpus striatum was dissected. 10µ thick sections were obtained by usual histological procedure and were stained with Glees Silver stain. Under light microscope, corpus striatum from experimental group revealed shrunken neurons and well defined fiber bundles surrounded by the glial cells. It was concluded that lead is toxic to central nervous system including corpus striatum which may be correlated to and may explain the clinical manifestation of lead neurotoxicity

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr S M Dawar Husain Neurohistological Effects of Lead on Corpus Striatum of Adult Albimo Rat International Journal of Scientific Research, Vol : 4, Issue : 8 August 2015

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