SERUM INFLAMMATORY MARKERS OF DIABETIC KIDNEY DISEASE AND THEIR CORRELATION TO LIPID PARAMETERS AMONG DIABETIC INDIVIDUALS OF EASTERN INDIA

Dona Acharjya; Ushasi Banerjee; Swati Bhattacharyya

Volume : VIII, Issue : I, January - 2019

SERUM INFLAMMATORY MARKERS OF DIABETIC KIDNEY DISEASE AND THEIR CORRELATION TO LIPID PARAMETERS AMONG DIABETIC INDIVIDUALS OF EASTERN INDIA

Dona Acharjya, Ushasi Banerjee, Swati Bhattacharyya

Abstract :

Background : Diabetes mellitus is the leading cause of chronic renal failure . As the period of diabetes progresses there is simultaneous increase of inflammatory markers like high sensitive C reactive protein (hsCRP) with degree of renal involvement, suggested by albumin creatinine ratio and also dyslipidemia in diabetic patients.

Materials & Methods: 120 diabetic individuals aged (30–60) yrs, divided in 3 groups of 40 subjects in each, namely: a) newly diagnosed˂5 years b) 5–10 years after diagnosis and c) ≥10 years after diagnosis were recruited as study subjects from a tertiary care hospital in sub Himalayan region.

Results : Descriptive studies showing mean values of hsCRP ,ACR & lipid parameters were done in all 3 groups. One–way ANOVA with post hoc analysis after Bonferroni correction in 3 different groups enunciated a significant and statistical increase (p <.001) of both hsCRP &ACR with duration of diabetes unlike the lipid parameters. hsCRP, ACR, cholesterol & LDL even illustrated a very significant correlation between each other (p<0.001) , TG to hsCRP while HDL showed no correlation to any parameters.

Conclusion: Early detection, monitoring of inflammatory markers hsCRP, ACR & deranged lipid parameters are predictors of diabetic nephropathy that can help in modulating diabetes and its complications.