Volume : VI, Issue : IX, September - 2017
SURVIVIN EXPRESSION IN COLORECTAL ADENOCARCINOMAS
Dr. S. Brihadisvarar, Dr. Nalli. R. Sumitra Devi
Abstract :
Introduction : Colorectal adenocarcinomas contribute to a significant proportion of cancer related morbidity and mortality. Survivin is a novel member of the IAP family of proteins involved in apoptosis inhibition, being overexpressed in many cancers. This study was done to evaluate the expression of Survivin in colorectal adenomas and adenocarcinomas and its association with the clinicopathological tumor characteristics.
Materials and methods : Immunohistochemical analysis of Survivin expression was performed
on 30 cases each of normal colorectal mucosa, adenomas and adenocarcinomas respectively.
Results: Survivin expression was absent in normal mucosa with increased expression in adenomas and maximal expression in adenocarcinomas. It also correlated with the degree of differentiation of adenocarcinomas.
Conclusion : The results indicate that dysregulation and over expression of Survivin is involved in colorectal tumorigenesis and malignant transformation of adenomas.
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DOI : 10.36106/ijsr
Cite This Article:
Dr.S.Brihadisvarar, Dr.Nalli.R.Sumitra Devi, SURVIVIN EXPRESSION IN COLORECTAL ADENOCARCINOMAS, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-9 | September-2017
Number of Downloads : 889
References :
Dr.S.Brihadisvarar, Dr.Nalli.R.Sumitra Devi, SURVIVIN EXPRESSION IN COLORECTAL ADENOCARCINOMAS, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-9 | September-2017
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