Unveiling the role of SHH from Embryogenesis to its reactivation in Tumorigenesis:A Maxillofacial Perspective.

Dr. Cristalle Soman

Volume : VIII, Issue : IV, April - 2019

Unveiling the role of SHH from Embryogenesis to its reactivation in Tumorigenesis:A Maxillofacial Perspective.

Dr. Cristalle Soman

Abstract :

Sonic Hedgehog gene (SHH) plays a vital role in emyogenesis through its secreted protein sonic hedgehog protein (Shh). During emyogenesis, Shh acts as a morphogen controlling proximal and distant signaling in the specific development of tissue lineages, patterning, regulation of cell proliferation and suppression of tissue apoptosis. Shh also exerts its role in odontogenesis by determining the site of tooth bud formation, in tooth morphogenesis and root formation. The difference in the specific development of a region by Shh can be explained by its [a] �Spatial gradient [b] the �form� [c] Concentration gradient and [d] Temporal gradient. Shh signaling pathway has an extracellular and an intracellular component. A disruption of Shh pathway contributes to tumorigenesis of several cell types including those arising from odontogenic structures. This article reviews Shh from its formation in emyonic stages, its role in development and odontogenesis, to its reactivation in tumorigenesis and in specific to odontogenic pathologies.