<?xml version="1.0"?>
<article>
<front>
<journal-meta>
<journal-id journal-id-type="publisher">IJSR</journal-id>
<journal-title>International Journal of Scientific Research</journal-title>
<issn pub-type="ppub">2277-8179</issn>
<publisher>
<publisher-name>Indian Society for Health and Advanced Research</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="other">ijsr-5-7-015</article-id>
<article-categories>
<subj-group>
<subject>Original Research Paper</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>A prospective interventional study of progression of diabetic retinopathy after uncomplicated small incision cataract</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name><surname>Chakraborti</surname><given-names>Chandana</given-names><prefix>Dr</prefix></name>
<xref ref-type="aff" rid="aff001"><sup>1</sup></xref>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Mukhopadhyay</surname><given-names>Udayaditya</given-names><prefix>Dr.</prefix></name>
<xref ref-type="aff" rid="aff002"><sup>2</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Agnihotri</surname><given-names>Akshyay</given-names><prefix>Dr.</prefix></name>
<xref ref-type="aff" rid="aff003"><sup>3</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Kumar</surname><given-names>Jayant</given-names><prefix>Dr</prefix></name>
<xref ref-type="aff" rid="aff004"><sup>4</sup></xref>
</contrib>
<aff id="aff001">Assistant Professor, <deptname>Department of Ophthalmology</deptname>, <instname>Calcutta National Medical College and Hospital</instname>, <instcity>Kolkata</instcity>, <inststate>West Bengal</inststate>, <instcountry>India</instcountry></aff>
<aff id="aff002">Associate Professor, <deptname>Ophthalmology</deptname>, <instname>North Bengal Medical College &#x0026; Hospital</instname>, <instcity>Siliguri</instcity>, <instaddress>District&#x2013;Darjeeling</instaddress>, <inststate>West Bengal</inststate></aff>
<aff id="aff003">PGT, R.I.O, <instname>Calcutta Medical College</instname> <instcity>Kolkata, Kolkata</instcity></aff>
<aff id="aff004">Fellow, <instname>Arvind Eye Hospital</instname>, <instcity>Maduri</instcity></aff>
</contrib-group>
<author-notes>
<corresp id="cor001">*Assistant Professor, <deptname>Department of Ophthalmology</deptname>, <instname>Calcutta National Medical College and Hospital</instname>, <instcity>Kolkata</instcity>, <inststate>West Bengal</inststate>, <instcountry>India</instcountry></corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>7</month>
<year>2016</year>
</pub-date>
<volume>5</volume>
<issue>7</issue>
<fpage>47</fpage>
<lpage>50</lpage>
<abstract><title>Abstract</title>
<p>Diabetes rates are rising all over the world and Diabetic Retinopathy (DR), one of the most frequent complications of diabetes, affects approximately 50% of diabetic subjects.</p>
<p>The purpose of this prospective study was to investigate the onset and course of diabetic retinopathy, the incidence of macular edema and visual outcome following uncomplicated phacoemulsification with Posterior Chamber Intra Ocular Lens implantation in a group of well controlled diabetic patients with cataractwith or without mild/moderate nonproliferative diabetic retinopathy and without Clinically Significant Macular Edema at baseline.</p>
<p>This study was done at the Regional Institute of Ophthalmology, Kolkata. Patients who gave informed consent and those meeting inclusion criteria were randomly selected from the outpatient department. 60 eyes of 60 consecutive diabetic patients having cataract with well controlled systemic parameters were included in the study conductedfrom January 2012 to June 2013.</p>
<p>Follow up was done for 6 months. Statistical analysis was done by chi square and Fisher&#x0027;s exact test.</p>
<p>The progression of diabetic retinopathy was statistically more significant in DR group compared to no DR group.</p>
<p>Also, statistically significant post operative improvement of VA in no DR group compared to DR group was seen.</p>
<p>&#x2265; 40 letters improvement occurred in 79.5 % of cases of without Macular Edema (ME) group whereas 27.2% of cases achieved the same in the macular edema group.</p>
<p>We found that the progression of diabetic retinopathy was 18.3% which was significantly more (29%) in DR group compared to 11% in No DR group. We also found that the incidence of ME is 18% which exclusively appeared in postoperative DR group. In conclusion, diabetic patients scheduled for cataract extraction should be informed that surgery may have an adverse influence on diabetic retinopathy and that this may affect the final visual outcome and expectation.</p>
</abstract>
<kwd-group>
<title>Keywords</title>
<kwd>Diabetic Retinopathy</kwd>
<kwd>Small incision cataract surgery</kwd>
<kwd>Macular edema</kwd>
</kwd-group>
<counts>
<ref-count count="22"/>
<page-count count="4"/>
</counts>
</article-meta>
</front>
<back>
<ref-list>
<title>REFERENCES </title>
<ref id="bib001"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Jaffe</surname><given-names>G.J.</given-names></name><name><surname>Burton</surname><given-names>T.C.</given-names></name></person-group> (<year>1988</year>). <article-title>Progression of nonproliferative diabetic retinopathy following cataract extraction</article-title>. <source>Arch Ophthalmol</source>; <volume>106</volume>: <fpage>745</fpage>&#x2013;<lpage>9</lpage>.</citation></ref>
<ref id="bib002"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Apple</surname><given-names>D.J.</given-names></name><name><surname>Mamalis</surname><given-names>N.</given-names></name><name><surname>Loftfield</surname><given-names>K.</given-names></name><etal/></person-group>  (<year>1984</year>). <article-title>Complications of intraocular lenses. A historical and histopathological review</article-title>. <source>Surv Ophthalmol</source><volume>c</volume>; <issue>29</issue>: <fpage>1</fpage>&#x2013;<lpage>54</lpage>.</citation></ref>
<ref id="bib003"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Alpar</surname><given-names>J.J.</given-names></name></person-group> (<year>1984</year>). <article-title>Cataract extraction and diabetic retinopathy</article-title>. <source>J Am Intraocul Implant Soc</source>; <volume>10</volume>: <fpage>433</fpage>&#x2013;<lpage>7</lpage>.</citation></ref>
<ref id="bib004"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Alpar</surname><given-names>J.J.</given-names></name></person-group> (<year>1987</year>). <article-title>Diabetes, cataract extraction and intraocular lenses</article-title>. <source>J Cataract Refract Surg</source>; <volume>13</volume>: <fpage>43</fpage>&#x2013;<lpage>6</lpage>.</citation></ref>
<ref id="bib005"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sebastyen</surname><given-names>J.G.</given-names></name></person-group> (<year>1986</year>). <article-title>Intraocular lenses and diabetes mellitus</article-title>. <source>Am J Ophthalmol</source>; <volume>101</volume>: <fpage>425</fpage>&#x2013;<lpage>8</lpage>.</citation></ref>
<ref id="bib006"><citation citation-type="book"><collab>Royal College of Ophthalmologists</collab>. (<year>1997</year>). <source>Guidelines for diabetic retinopathy</source>. <publisher-loc>London</publisher-loc>: <publisher-name>RCO</publisher-name>,.</citation></ref>
<ref id="bib007"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cunliffe</surname><given-names>I.A.</given-names></name><name><surname>Flanagan</surname><given-names>D.W.</given-names></name><name><surname>George</surname><given-names>N.D.L.</given-names></name><etal/></person-group>  (<year>1999</year>). <article-title>Extra capsular cataract surgery with lens implantation in diabetics with and without proliferative retinopathy</article-title>. <source>Br J Ophthalmol</source>;<volume>75</volume>:<fpage>9</fpage>&#x2013;<lpage>12</lpage>.</citation></ref>
<ref id="bib008"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pollack</surname><given-names>A.</given-names></name><name><surname>Dotan</surname><given-names>S.</given-names></name><name><surname>Oliver</surname><given-names>M.</given-names></name></person-group> (<year>1991</year>). <article-title>Progression of diabetic retinopathy after cataract extraction</article-title>. <source>Br J Ophthamol</source>;<volume>75</volume>:<fpage>547</fpage>&#x2013;<lpage>51</lpage>.</citation></ref>
<ref id="bib009"><citation citation-type="report"><collab>Early Treatment Diabetic Retinopathy Study Research Group</collab>. <article-title>Photocoagulation for diabetic macular edema: Early Treatment Diabetic Retinopathy Study report number 1</article-title>.(<year>1985</year>). <source>Arch Ophthalmol</source>;<volume>103</volume>:<fpage>1796</fpage>&#x2013;<lpage>806</lpage>.</citation></ref>
<ref id="bib010"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Krepler</surname><given-names>K.</given-names></name><name><surname>Biowski</surname><given-names>R.</given-names></name><name><surname>Schrey</surname><given-names>S.</given-names></name><name><surname>Jandrasits</surname><given-names>K.</given-names></name><name><surname>Wedrich</surname><given-names>A.</given-names></name></person-group> (<year>2002</year>). <article-title>Cataract surgery in patients with diabetic retinopathy: visual outcome, progression of diabetic retinopathy, and incidence of diabetic macular edema</article-title>. <source>Graefes Arch Clin Exp Ophthalmol</source>;<volume>240</volume>:<fpage>735</fpage>&#x2013;<lpage>8</lpage>.</citation></ref>
<ref id="bib011"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Mittra</surname><given-names>R.A.</given-names></name><name><surname>Borrillo</surname><given-names>J.L.</given-names></name><name><surname>Dev</surname><given-names>S.</given-names></name><name><surname>Mieler</surname><given-names>W.F.</given-names></name><name><surname>Koenig</surname><given-names>S.B.</given-names></name></person-group><article-title>Retinopathy progression and visual outcomes after phacoemulsification in patients with diabetes mellitus</article-title>. (<year>2000</year>). <source>Arch Ophthalmol</source>;<volume>118</volume>:<fpage>912</fpage>&#x2013;<lpage>7</lpage>.</citation></ref>
<ref id="bib012"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zaczek</surname><given-names>A.</given-names></name><name><surname>Olivestedt</surname><given-names>G.</given-names></name><name><surname>Zetterstrom</surname><given-names>C.</given-names></name></person-group> (<year>1999</year>). <article-title>Visual outcome after phacoemulsification and IOL implantation in diabetic patients</article-title>. <source>Br J Ophthalmol</source>;<volume>l83</volume>:<fpage>1036</fpage>&#x2013;<lpage>1041</lpage></citation></ref>
<ref id="bib013"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Borillo</surname><given-names>J.L.</given-names></name><name><surname>Mittra</surname><given-names>R.A.</given-names></name><name><surname>Dev</surname><given-names>S.</given-names></name><etal/></person-group>  (<year>1999</year>). <article-title>Retinopathy progression and visual outcomes after phacoemulsification in patients with diabetes mellitus</article-title>. <source>Trans Am Ophthalmol Soc</source>; <volume>97</volume>: <fpage>435</fpage> &#x2013; <lpage>45</lpage></citation></ref>
<ref id="bib014"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Rema</surname><given-names>M.</given-names></name><name><surname>Premkumar</surname><given-names>S.</given-names></name><name><surname>Anitha</surname><given-names>B.</given-names></name></person-group> (<year>2005</year>). <article-title>Prevelance of diabetic retinopathy in Urban India: The Chennai Urban Rural Epidemiology Study (CURES) eye study1</article-title>. <source>Invest Ophthalmol Vis Sci.</source>;<volume>46</volume>:<fpage>2328</fpage>&#x2013;<lpage>33</lpage>.</citation></ref>
<ref id="bib015"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Klein</surname><given-names>B.E.</given-names></name><name><surname>Klein</surname><given-names>R.</given-names></name><name><surname>Moss</surname><given-names>S.E.</given-names></name></person-group> (<year>1995</year>). <article-title>Incidence of cataract surgery in the Wisconsin Epidemiologic Study of Diabetic Retinopathy</article-title>. <source>Am J Ophthalmol.</source>;<volume>119</volume>:<fpage>295</fpage>&#x2013;<lpage>300</lpage></citation></ref>
<ref id="bib016"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bernth-Peterson</surname><given-names>P.</given-names></name><name><surname>Bach</surname><given-names>E.</given-names></name></person-group> (<year>1983</year>). <article-title>Epidemiological aspects of cataract surgery. Frequencies of diabetes and glaucoma in a cataract population</article-title>. <source>Acta Ophthalmol</source>;<volume>61</volume>:<fpage>406</fpage>&#x2013;<lpage>416</lpage>.</citation></ref>
<ref id="bib017"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Saxena</surname><given-names>S.</given-names></name><name><surname>Mitchell</surname><given-names>P.</given-names></name><name><surname>Rochtchina</surname><given-names>E.</given-names></name></person-group> (<year>2004</year>). <article-title>Five-year incidence of cataract in older persons with diabetes and pre-diabetes</article-title>. <source>Ophthalmic Epidemiol.</source><comment>Oct</comment>;<volume>11</volume>(<issue>4</issue>):<fpage>271</fpage>&#x2013;<lpage>7</lpage>.</citation></ref>
<ref id="bib018"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Henricsson</surname><given-names>M.</given-names></name><name><surname>Heijl</surname><given-names>A.</given-names></name><name><surname>Janzon</surname><given-names>L.</given-names></name></person-group> (<year>1996</year>). <article-title>Diabetic retinopathy before and after cataract surgery</article-title>. <source>Br J Ophthalmol</source>; <volume>80</volume>:<fpage>789</fpage>&#x2013;<lpage>93</lpage>.</citation></ref>
<ref id="bib019"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pollack</surname><given-names>A.</given-names></name><name><surname>Lebia</surname><given-names>H.</given-names></name><name><surname>Bukelman</surname><given-names>A.</given-names></name><name><surname>Oliver</surname><given-names>M.</given-names></name></person-group> (<year>1992</year>) <article-title>The course of diabetic retinopathy following cararact surgery in eyes previously treated by laser photocoagulation</article-title>. <source>Br J Ophthalmol</source>; <volume>76</volume>:<fpage>228</fpage>&#x2013;<lpage>31</lpage></citation></ref>
<ref id="bib020"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Mittra</surname><given-names>R.A.</given-names></name><name><surname>Borrillo</surname><given-names>J.L.</given-names></name><name><surname>Dev</surname><given-names>S.</given-names></name><name><surname>Mieler</surname><given-names>W.F.</given-names></name><name><surname>Koenig</surname><given-names>S.B.</given-names></name></person-group> (<year>2000</year>). <article-title>Retinopathy progression and visual outcomes after phacoemulsification in patients with diabetes mellitus</article-title>. <source>Arch Ophthalmol</source>;<volume>118</volume>:<fpage>912</fpage>&#x2013;<lpage>7</lpage>.</citation></ref>
<ref id="bib021"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Dowler</surname><given-names>J.G.</given-names></name><name><surname>Sehmi</surname><given-names>K.S.</given-names></name><name><surname>Hykin</surname><given-names>P.G.</given-names></name></person-group> (<year>1999</year>). <article-title>The natural historyof macular oedema after cataract surgery in diabetes</article-title>. <source>Ophthalmology</source>; <volume>106</volume>: <fpage>663</fpage>&#x2013;<lpage>668</lpage>.</citation></ref>
<ref id="bib022"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pollock</surname><given-names>A.</given-names></name><name><surname>Leiba</surname><given-names>H.</given-names></name><name><surname>Bukelman</surname><given-names>A.</given-names></name><name><surname>Oliver</surname><given-names>M.</given-names></name></person-group> (<year>1992</year>). <article-title>Cystoid Macular oedema following cataract extraction in patients with diabetes</article-title>. <source>Br J Ophthalmol</source>; <volume>76</volume>: <fpage>221</fpage> &#x2013; <lpage>224</lpage></citation></ref>
</ref-list>
</back>
</article>
