IJSR International Journal of Scientific Research 2277-8179 Indian Society for Health and Advanced Research ijsr-5-10-002 Original Research Paper Endoscopic biopsy interpretation of upper gastrointestinal pathologies GumberRituDr. 1 MulaySmita S.Dr. 2 MBBS, Pathology – Consultant Pathologist – Metropolis - Bangalore M.D. Pathology- Professor& HOD, Department of Pathology, MGM Medical College, Aurangabad, Maharashtra (Both authors) 10 2016 5 10 4 8 Abstract

OBJECTIVES: Endoscopy in combination with endoscopic biopsy plays an important role in the diagnosis of upper gastrointestinal tract (GIT) neoplasms and hence early management. The objective of this study is to find the spectrum of non-neoplastic and neoplastic conditions of upper GI lesions which are diagnosed on endoscopic biopsy and find association with age, sex and H. Pylori. Also to find out precancerous lesions so as to keep follow up of the patient.

METHODS: There were 150 upper GI biopsies received during the period of 2011-2013. The biopsies were taken under aseptic precautions in the Endoscopy department of MGM Medical College & Hospital. The biopsies were fixed in 10% formalin and stained with H & E & special stain Giemsa. The biopsies were reported later as either being non neoplastic or neoplastic with further typing of the tumour.

RESULTS: Among the 150 biopsies, 88 (58. 7%) biopsies were non neoplastic and 62 (41.3%) were neoplastic. The male female ratio was 1.17:1. The neoplastic lesions were most common in 6th -7thdecade. The most common non neoplastic lesion wasChronic gastritis seen in 35 (23.3%) biopsies. The malignancies were squamous cell Carcinoma seen in 30 (20%) biopsies, Adenocarcinoma seen in 30 (20%) biopsies and Adenosquamous carcinoma in 2 (1.4%) biopsies. 10 (6.6%) biopsies were also reported as dysplasia and suspicious of malignancy. Adenocarcinomas were also typed being signet ring adenocarcinoma. The incidence of H. Pylori was found to be 23% in chronic gastritis biopsies.

CONCLUSION: Upper GI endoscopy and biopsy is a convenient tool for accurate objective assessment of patients with gastrointestinal symptoms and can be used as a tool for early diagnosis of neoplasticlesions of the upper GIT. Since the tissue bits may not be representative of the disease, the diagnosis could be missed hence complete assessment and follow up of the patient is necessary and at times repeat Biopsy is needful.

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