– A patient who suffers from type 2 diabetes has a 2–4 times greater risk of death from cardiovascular causes than the patient without diabetes. Thus, chances of concomitant administration of CVS drugs such as anti–anginal, anti–hypertensive and others along with the anti–diabetic drugs is a common therapeutic strategy for the treatment of patients suffering from diabetes with CVS diseases. 

 So, this study was planned to evaluate the interaction of Glipizide with Nicorandil on blood glucose level in alloxan induced diabetic mice. This study on drug interaction of nicorandil (3 mg/kg p.o.), glipizide (2.5 mg/kg p.o.) and combination of glipizide with nicorandil (2.5 + 3 mg/kg, p.o.)  showed that glipizide reduced blood glucose levels at 2, 3 and 5 hrs period and the difference were statistically significant at 3 and 5 hrs in comparison to control group.

The study also showed insignificant lowering of blood glucose by nicorandil as compared to control group (p>0.05). However, statistically significant difference was observed in comparison to glipizide group at 3 and 5 hrs. (p<0.05). Nicorandil per se has not reduced blood glucose level as it is reduced by glipizide group. Similarly, the combination group (G+N) did not produce any significant change in blood glucose levels as compared to control group at 2,3 and 5 hours. Yet, at 5 hr the effect of combination was significant as compared to glipizide group (p<0.05). It also increases blood glucose level in combination group even in presence of glipizide. Thus, Combination group found to reduce efficacy of glipizide when nicorandil was administered in combination,

So, on the basis of this study we conclude that Glipizide per se lower blood glucose level in diabetic mice and Nicorendil per se hinder reduction in blood glucose level. It may reduce efficacy of glipizide when administered in combination, suggesting nicorendil should be avoided as anti–anginal or anti–hypertensive drug in patients suffering from diabetes with CVS diseases or proper glucose monitoring should be done.