100 cases of ischemic heart disease attended medicine OPD or admitted to Medicine ward, Civil Hospital, P.D.U. government medical college, Rajkot fromare included in study.     All the patients of ischemic heart disease with age group 31–60 were clinically evaluated and underwent relevant investigation like hemoglobin estimation, total leukocyte count, differential leukocyte count, platelet count, RBS, serum creatinine, serum urea, 12 lead ECG as well as two–dimensional echocardiography. Echocardiographic evaluation done in each patient specifically to assess the regional wall motion abnormality  (RWMA)  by two–dimensional echocardiography.RWMA is assessed as normal, hypokinesia, akinesia or dyskinesia. The patients of ischemic heart disease are divided into three groups: stable angina, unstable angina and myocardial infarction. Study for regional wall motion abnormality (RWMA) shows that regional wall motion is less affected in cases of stable angina (27.90%), while in cases of acute coronary syndromes it is more affected (57.89%). Among RWMA, Hypokinesia is more observed in unstable angina (59.25%), while its prevalence is less in stable angina (27.09%) and myocardial infarction (53.33%) as compare to unstable angina and akinesia observed only in myocardial infarction. Evaluation of RWMA is significant as absent or transient RWMA suggest good prognosis, while RWMA predicts unfavorable prognosis.