Introduction: Large intestine is a common site for malignancies. This study was undertaken to determine the histomorphological spectrum of these malignancies, and their burden in areas nearby our institute. Methods: This study is carried out in the department of pathology, Sardar Patel Medical College and associated group of hospitals, Bikaner for a period of 28 months. Results: Colon and rectum constituted 68 cases (90.66%), 5 (6.66%) cases of anal canal and only 2 (2.66%) cases of appendix. Peak occurrence was in 6th decade with male to female ratio 0.8:1. Adenocarcinoma constituted 82.35%, mucinous adenocarcinoma 7.35%, and SCC 5.88%, two cases of malignant melanoma and single case of signet ring cell carcinoma. Majority of adenocarcinomas were moderately differentiated. Adenocarcinoma was commonest finding even in appendix and anal canal. Conclusion: Left sided colon was the most common site for malignancies of large intestine. Histopathological examination aids in early detection and proper treatment.