Generalized pustular psoriasis is a serious dermatological disease characterized by fever, chills and generalized pustulosis on the skin. Although, Etanercept is FDA approved biological for plaque type psoriasis, we gave a trial of this drug in a dose of 25mg/week for twelve doses with successful outcome. Case report: A 70 years old male with ten years history of chronic plaque psoriasis had one and half year’s history of recurrent flares of pustular psoriasis. Histopathology confirmed the diagnosis of pustular psoriasis. Patient was treated with many systemic drugs including steroids, oral Acitretin, oral Cyclosporine and injection Methotrexate with no significant improvement. Considering unfavorable outcome with above drugs and adverse effects with long term steroids, patient was started on injection Etanercept 25 mg weekly with successful remission after twelve injections. Conclusion: We hereby report successful outcome while treating recalcitrant pustular psoriasis with low dose Etanercept.