Understanding the relationship between periodontal disease (PD) and systemic health (SH) is necessary for the accurate diagnosis and treatment of both. The aim of this study was to evaluate the knowledge of medical doctors in El Madinah with regard to the association between PD and SH. This study was carried out using self–reported questionnaires that were sent to medical doctors who work at various universities and public and private hospitals in different area in Madinah. The questionnaires consisted of questions about the demographic information of the medical doctors, as well as the knowledge of those doctors about the relationship between PD and SH. In total, 159 responses .The demographic data for the physician are shown in males participants was 62.9%, and female participants was 37.1%. Doctors who had ≤ 10 years of practice constituted 83.6%, and 16.3% of the doctors had less than 10 years of practice .