Background: laparoscopic cholecystectomy is the surgery of choice in any gall bladder surgery around the world  nowadays. The main advantage is the reduction in trauma, reduced adhesion formation, early ambulation, short hospital stay, less medication & early return to work and daily activities.our aim was to compare the changes in liver functions after minimal invasive and open cholecystectomy. Materials and methods: the study was conducted Ina tertiary care teaching centre in Kerala after getting ethical committee clearance and institutional research committee clearance.we selected 30 consecutive patients undergoing laparoscopic cholecystectomy and 16 patients undergoing open cholecystectomy. Inclusion criteria: patients between 13 to 60 years, with normal preoperative liver function tests  only was considered. Exclusion criteria: Patients with preoperative liver failure, portal hypertension and cirrhosis ,with any previous history of intra abdominal operations in the upper abdomen were excluded from the study. Patients who developed complications such as bile duct injury, obstruction,infection, bile leakage, and high grade fever in the post operative period were excluded from the study. Patients who underwent endoscopic procedures within one week prior to operation were also excluded from the study. Results: In our study, there was a statistically significant difference in the changes in liver functions in the laparoscopic group as compared to the open cholecystectomy on the first post an operative day. Moreover,  there were no statistically significant changes in the liver function test at the end of first week from the preoperative value in the laparoscopic group compared to open cholecystectomy group.Discussion: In laparoscopic surgery,  there is a short term elevation in the liver function test in patients in the immediate post operative period which recover to preoperative values as compared to the open cholecystectomy group. This elevation in the liver function test could be due to the effect of reduced  blood flow to the liver due to pressure effects produced by the pneumoperitoneum.