Background: COPD is leading cause of morbidity and mortality worldwide. The major morbidity of COPD is due to its impact on cardiac performance caused by pulmonary hypertension. This study attempts to assess the ECG and ECHO changes in COPD and to correlate with the duration and severity of the disease. Methods: 50 patients of COPD admitted to Alluri Sitaramaraju Academy of Medical Sciences, Eluru between September 2014 to September 2015, who met inclusion criteria were randomly selected. Detailed history and physical examination findings were recorded. Investigations like CXR, ECG, 2D ECHO, Spirometric evaluation of FEV1, FVC and ratio of FEV1/FVC were done. Results: The mean age of presentation was 66.87 ± 7.21 years with male predominance. Mean duration of dyspnoea 7.013 ± 5.0439 and cough of 9.092 ± 6.303 years. Majority of patients had severe disease and had smoking history more than 20 pack years (mean 56.9 ± 23.99). ECG and Echo findings that showed significant correlation with severity were ‘p’ pulmonale, right axis deviation, right bundle branch block, right ventricular hypertrophy and poor ‘r’ wave progression, RA & RV dilatation, RV failure, pulmonary hypertension and  cor–pulmonale. Diagnosis   of   cor–pulmonale   clinically   was   36%,   ECG 44%, Echocardiographically 54%. Conclusion: COPD is more common in males in the 6th and 7th decade. Most of them have fairly advanced disease at presentation. The incidence of ECG and ECHO findings increase as the severity and duration of disease increases and echocardiography is better than ECG or clinical methods in detecting RV Dysfunction.