IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-6-3-10243 Original Research Paper Growth performance of Indian under five children with endocrine disorders on WHO 2006 growth standards Ruma Deshpande Dr. March 2017 6 3 01 02 ABSTRACT

  With the objective to assess height parameters of Indian under five children with endocrine growth disorders attending a specialty paediatric clinic with respect to WHO2006 Growth Standards .the study was conducted retrospectively. 768 children less than 5 years, who presented with either abnormal stature due to an endocrine cause or specific clinical features, were selected for the study. Healthy age and sex matched children were recruited as controls (n=824). Height measurements were converted to SD scores (WHO Anthro 2005). Results: Significant co–relation was present between the Z–scores for height based on IAP references and WHO standards. Mean height of overgrowth disorders (precocious puberty (PP), constitutional tall stature (TS) and nutritional obesity), controls, other endocrinopathies (premature thelarche, congenital Adrenal Hyperplasia (CAH) & Type 1 diabetes mellitus (T1DM)) and hypothyroid children were on the 50th, 25th, 5th and 1st percentiles respectively. Children with familial short stature (FSS), syndromic short stature and growth hormone deficient (GHD) children positioned themselves in the same order below the 1st percentile. Mean height for age Z–scores in TS, nutritional obesity, premature thelarche, CAH, T1DM, hypothyroidism, FSS, Syndromic short stature and GHD were  0.14, 0.41, –1.6, –2.2, –1.5, –2.4, –3.1, –4.5 and –5.02 respectively. The percentage of children with severe stunting (height for age Z–score < –3) in the above groups were 0%, 0%, 5.9%, 32.5%, 7.8%, 38.9%, 51.5%, 77% and 92% respectively.