Objectives: To study the clinical profile & clinical course with progression of disease & to analyse the precipitating factors of hepatic encephalopathy, in P.D.U. government civil hospital, Rajkot from august 2013 to march 2016. Methodology: Fifty addmitted patients with liver disease were examined based on history, clinical examinations and laboratory methods including analysis and prognostic stratification through Child’s Pugh classification was also carried out. Results: G.I. bleeding (62%), Infection (62%), Constipation (56%) were most common factors. Most were in grade 2 and 3 of hepatic encephalopathy. Other associations were ascites (80%) and hepatomegaly (80%), Child’s Pugh class c (50%), non b & c cirrhosis (68%) and Mortality rate (42%). Conclusion: Early detection and diagnosis of these factors helps in starting treatment of this fatal condition hence reducing the mortality.