Background: The association of serum trace element like Zinc has been found in different types of cancer. This study was conducted to see the serum level of trace element (Zn) in carcinoma of lung and esophagus patients. Material and methods: Study group consisted of 50 clinically diagnosed subjects (Biopsy confirmed 25 cases with Lung carcinoma and 25 cases with Esophageal carcinoma). The control group consisted of 50 Healthy subjects were included in the study. Both study and control group patients were of same socio–economic status and dietary habits. Venous blood samples of each lung and esophagus cancer were obtained and serum Zn levels was analysed by Atomic Absorption Spectrophotometer measurements. Results: The serum Zn level was significantly lower in serum of lung and esophagus cancer group than controls (P<0.0001). Conclusions: Serum trace element like zinc, might be play a role in the patients of cancers. Zn may protective as potent lung cancer. In addition, it is suggested that low levels of zinc can induce the pathogenesis of cancer.