Oropharyngeal cancers are the 8th most common cancer worldwide. In India oral cancer is the most common cancer with an age standardized incidence of 12.6 per 100,000 populations. [1] Our Aim is to study the reliability and effectiveness of chemiluminesence as a non invasive screening tool for oral pre cancers and to compare the results with gold standard of biopsy. We have studied 100 patients with in the age group of 21 – 70 years with oral precancers in a cross sectional, intervention study, where after clinical examination patients were screened by chemiluminesence using Vizilite light sticktm and were then subjected to biopsy. The data was then subjected to statistical analysis. Permission of institutional ethics committee of GMC Gondia was taken. Study duration was from August 2016 to January 2017.     AIM:  Our AIM is to study the effectiveness of non invasive screening method  (chemiluminesence) for oral precancers and to compare its sensitivity and specificity in screening oral precancer lesions with the gold standard of biopsy.   Materials & Methods: We have studied 100 patients within the age group of 21 – 70 years with oral precancers (premalignant lesions) in a cross sectional, interventional study, where after clinical examination patients were screened by chemiluminescence and incision biopsy was taken to compare the results. Vizilite plus TM was used as a source of chemiluminesence. The data was then statistically analysed. Results :  In our study chemiluminesence has sensitivity, specificity, positive predictive value, negative predictive value of 58%, 71%, 76% and 50.94%. With 28 true negative, 34 true positive, 25 false negative and 13 false positive results. In our study chemiluminesence has high false negative cases with low sensitivity and low negative predictive value. Conclusion:  In our study chemiluminesence has high false negative cases with low sensitivity and low negative predictive value we totally agree that further studies are required to evaluate the full potential of chemiluminesence  as a diagnostic adjunct in demarcating oral premalignant lesions.