The nurses have a major influence on the behavior  of  our  women,  they  need  to  be knowledgeable themselves about breast cancer risk  factors  and  the  importance  of  early detection through screening ,  thereby improving a chance of longer life for the patient.The need of the hour is to create awareness and bring forth the importance of breast self examination for early management of this disease. The present Pre–Post test study was carried out among female students in a Government College of Nursing in Nagpur to assess the impact of educational intervention on awareness and practices of Breast Self Examination (BSE) using a predesigned self administered questionnaire. The overall knowledge of BSE significantly increased from 25.5% in Pretest to 82.83% in Post test. The impact of intervention shows significant increase in knowledge and practice of BSE.