Juvenile SLE is an autoimmune disease with multisystem involvement leading to inflammatory damage to joints, heart, lungs, kidneys and central nervous system. We are presenting the case of a patient with recurrent admissions to the general medicine ward for fever who was eventually diagnosed as having juvenile systemic lupus erythematosus (SLE). Despite maximum immunosuppression, patient succumbed due to concomitant neurological, cardiovascular and renal system involvement.