IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-6-3-10332 Original Research Paper STUDY OF SERUM URIC ACID LEVELS IN ACUTE MYOCARDIAL INFARCTION AND IT’S PROGNOSTIC SIGNIFICANCE T V D Sasi Sekhar Dr. Dr. D. Anusha Dr. March 2017 6 3 01 02 ABSTRACT

 BACKGROUND: Acute myocardial infarction (AMI) is overwhelmingly the most important form of ischemic heart disease (IHD) which continues to be the leading cause of death in the industrialized and developing countries like India, despite spectacular progress in their prevention, detection and treatment over the last three decades. The relation between uric acid and cardiovascular disease is observed not only with frank hyperuricemia (defined as more than 6mg/dl in women & more than 7 mg/dl in men) but also with uric acid levels considered to be normal but at high range. AIMS AND OBJECTIVES 1.      To study the serum uric acid level of patients of Acute Myocardial Infarction admitted to our hospital. 2.       To correlate the serum uric acid levels on day 0,3,7 and  compare with killips class with coefficient of correlation. 3.      To study the morbidity and mortality of these patients. METHODS: This hospital based case  study was performed in Dr. PSIMS & RF, Chinoutpalli , Krishna district, Andhra Pradesh from October 2013  to September 2014. A total of 75 cases of Acute MI were studied. All the subjects were interviewed ,  examined and investigated as per the predesigned proforma.. RESULTS: 75 cases of acute MI were included in the study. Mean SUA for discharged patients was 4.67 ±1.95 /dl and it was 7.1 ±1.45 mg/dl for the patients who died in the hospital. SUA levels were significantly higher in the patients who succumbed as compared to those who were discharged from the hospital. CONCLUSION: 1.Serum uric levels are correlated with killip’sclassification.Patients of higher killips class have higher uric acid levels. 2.Combination of  killip’s class and serum uric acid levels after acute myocardial   infarction is a good predictor of mortality. 3. Serum uric acid levels were high in the patients who died in the seven day  follow up period and the patients who died were also in higher killip’s class.