Diabetes mellitus (DM) is metabolic disorder showing multiple network associations with aging diseases. A.squamosa raw fruit peel aqueous extract was tested for antidiabetic activity. Wister albino rats weighing about 150–200 g were used in the present study. The aqueous raw fruit peel extract of A.squamosa caused reduction in fasting blood glucose level. The decrease in cholesterol, serum triglycerides and HDL and increase in increase in LDL shows significant effect of aqueous raw fruit peel extract of A.squamosa as antidiabetic agent.