IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-6-4-10540 Original Research Paper Effect of glycemic control on serum C reactive protein and development of nephropathy in type 2 diabetes mellitus. Mathur Dr. Dharamveer Yadav Dr. April 2017 6 4 01 02 ABSTRACT

 Aim: To assess the association between serum CRP concentration and the risk of development of diabetic nephropathy with glycemic control. 

Material and Methods: A hospital based observational study was conducted on ninety clinically established non–insulin dependent diabetes mellitus (NIDDM) subjects having relevant clinical and laboratory measurements. subjects were divded into two groups on the basis of urinary albumin excretion. Urinary albumin excretion was measured by qualitative Dipstick method. CRP  and HbA1C were measured using Immunoturbidimetric assay & Latex agglutination inhibition assay respectively.

Results: The mean HbA1C level and serum CRP levels in diabetic subjects with microalbuminuria were higher and statistically significant (P ≤ 0.001). The serum CRP levels and HbA1C levels in NIDDM subjects were statistically significant and positively correlated (P < 0.001 and r = 0.92).

Conclusion: In this study, the  serum CRP concentrations increased with increasing HbA1C levels.which, suggests an association between glycemic control and systemic inflammation in people with established diabetes.