Depression is a common mental disorder, with an estimated global burden of 350 million. Our study aimed to evaluate the levels of CRP , thyroid stimulating hormone and Prolactin in adult  patients with minor depression classified by CES– D scale.  The study was conducted on 65 individuals of 35– 55 years with minor depression visiting IPGMER and SSKM Hospital, who give consent and answered the questionaers. We included 65 healthy individuals as control. We observed a significant difference in TSH and prolactin between group D and control (p<0.001) and elevated levels of CRP are independently associated with depressive symptoms in group D (p <0.04) .An early recognition of an endocrine condition and inflammation may help minimize psychiatric morbidity.