Background : In a normal setting wounds have a well orderly and timely healing process that ends in proper restoration of anatomical and functional intergrity. Biological dressing material adhere well to the wound, helps to reduce the pain, limits infection and optimize the rate of healing. Materials and methods: Prospective study, comparative  trial among patients admitted with chronic ulcers in general surgery wards at a tertiary referral hospital from may 2013to april 2014. 60 patients were randomized into collagen or conventional group of 30 each. Results: In conventional dressing group the duration of hospital stay was on an average of 60.3 days whereas in collagen dressing it took 36.11 days P<0.001 significant. Infection was present in 70% of patients in the conventional group and in only 20% of patients in collagen group P<0.021 significant. 76% of patients in conventional group undergone split skin graft and 26% of patients in the collagen group has undergone split skin graft.Patient compliance was good in collagen group than conventional group. Conclusion. Collagen dressing reduces the duration of hospital stay and decrease the need of analgesics. Because of the simple application and good tolerance of the collagen granule, collagen granule can be advocated as a temporary biological dressing material in chronic non healing ulcer.