Aim: The aim of this study was to investigate the age– and gender–dependent changes of salivary IgA levels among healthy subjects.

Materials and Methods: A total of 150 healthy individuals (aged 1–70 years) were enrolled in the study. Two milliliters of saliva were collected from all participants, and salivary IgA levels were measured by the ELISA technique.

Results: Mean salivary IgA levels were significantly higher in subjects aged 11–20 years as compared to subjects aged 1–10 years (P < 0.01). Mean salivary IgA levels increased with age up to the age of 60 years, and then slightly decreased in subjects aged 61–70 years. No significant differences were observed between men and women regarding salivary immunoglobulin levels.

Conclusion: These results showed age–dependent changes of the salivary IgA levels. Gender had no effect on the salivary levels of IgA.