Background: Severe hemolytic anemia leads to shorter life span and sickle cell anemia (SCA) may be main cause of it. Early Diagnosis plays an important role in management of the disease. Objective: To assess the efficacy of Super Speed Sickle Solubility test in the diagnosis of SCA in population attending this medical institute. Material and Methods: In the present study, A total of 63  patients were screened. All the positive samples were assayed by solubility test and simultaneously analyzed on high–performance liquid chromatography (HPLC) ‘BIO–RAD’ Variant II analyzer for the confirmation along with the distinction of SCA (heterozygous) and sickle cell disease (homozygous). Results: Out of all 63 patients screened, 29 were found to be positive with HPLC as well as with solubility test too. A total of 10 samples was diagnosed as SCA (heterozygous) , 12  samples were diagnosed as sickle cell homozygous & 7 cases as Sickle Thal  with HPLC & Solubility tests . Conclusion: in case of Sickle cell Homozygous Solubility test was found to be  fairly effective with 75.0 % sensitivity. Specificity calibrated was, on average 80.85 %, with the predictive value of positive test  57.14% and a predictive value of negative test 90.47 % along with an Accuracy of 79.37 % . It was observed in case of Sickle Cell Trait,  the sensitivity was 76.92 %, Specificity 97.5 %,Positive predictive value 57.14, Negative Predictive Value 92.8% with an Accuracy rate of 77.77 %. We found that Solubility test in Sickle Thal Trait  revealed sensitivity of 70.0 %, specificity73.58 %, positive predictive value 33.33 %, negative predictive value 92.85 % along with an Accuracy of 73.0 %. We concluded that solubility test is better for mass screening and does not need any microscope . It is also a cost effective test for early detection of disease for timely intervention to minimize morbidity and mortility.