Introduction.

As a dual reuptake inhibitor of serotonin and nor–adrenaline, Desvenlafaxine is designated as newer antidepressant drug used for treatment of various depressive disorders.

Methods. 

Swiss albino mice were given Desvenlafaxine in the dose of 80mg per kg body wt for first 6 days of gestation (group 2) and from gestation days 1–18(group 3).controls were treated with equivalent amount of tap water respectively(Group 1).

Result

Cerebral cortex of group 2, showed mild alteration in the laminar pattern of frontal cortex. Group 3 cortex, showed marked oedematous space with cellular necrosis.

Conclusion.

Above changes suggest probable role of desvenlafaxine in causing oxidative damage to frontal cortex of swiss albino mice.