Gastrointestinal stromal tumors are the most common primary non–epithelial tumors of stomach. They are unique owing to origin due to activation of KIT mutation and subsequent expression of KIT proteins.

A 45 year male patient presented with mass in right lumbar region since 15 days, with no other positive history. Mass cystic in consistency, ill defined margins, smooth surface and moves with respiration. Tomographic scan and fine needle cytology confirmed it as GIST. Intra–operative, pedunculated mass was evident arising from stomach extending upto fat plane of transverse mesocolon. Patient managed with subtotal gastrectomy with Billroth–II procedure. Biopsy

report confirmed the diagnosis as GIST tumor with high malignant potential with high mitotic rate with no lymphadenopathy.

GIST, a relatively well circumscribed neoplastic lesion are considered as tumors with uncertain malignant potential.