The aim of present study was to assess the extent of altered pulmonary function tests and Hematological parameters in petrol–pump workers exposed to petrol and diesel fumes. The study group consisted of 10 males in the age group of 20–50 years, working 8 hours per day for more than 5 years in various petrol stations as petrol attendants in Hyderabad region of Telangana state. The control group consisted of 10 males of matched age group, not exposed to petroleum vapors. Complete blood count analysis comprising Hb concentration, RBCs counts, values of MCV and MCHC, Total WBC with differential counts, platelets and Pulmonary functions parameters comprising Forced Vital Capacity (FVC), Forced Expiratory Volume in first second (FEV1), FEV1 /FVC, Peak Expiratory Flow Rate (PEFR) and Forced Expiratory Flow at 25–75% were investigated and analyzed comparatively between the exposed and unexposed subjects using unpaired t test to evaluate any statistically significant differences. FVC, FEV1, PEFR, FEF 25–75 among the pulmonary function tests and platelet and neutrophils in hematology analysis were found significantly lower to the unexposed group. It may thus be concluded that the petroleum products and its fumes have equivocal affects on hematology parameters but certain and deleteriously restrictive affects on pulmonary function tests thereby making them vulnerable to a variety of restrictive lung disorders.