IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-6-5-10749 Original Research Paper Comprehensive study of corneal ulcer. Trupti Mahesh Solu Dr. Dr. Saurabh patel Dr. May 2017 6 5 01 02 ABSTRACT

 Background– Corneal ulceration can progress rapidly, threatening the integrity of eye and producing significant visual impairment. Aims and Objectives– To study risk factors, causative organism and the outcome of treatment in corneal ulcer. Materials and Methods– Total 64 patients of corneal ulcer, who attended the Out–door patient from November 2011 to October 2013 were studied. Ophthalmological evaluation and microbiological investigations were done followed by treatment outcome analysis. Result– 43(67%) patients were between 21– 60 year age , male: female ratio was 1.5:1, 51(80%) belonged to low socio–economic group. 56% patients were either farmer or labourer. 24(37.5%) patients had history of ocular trauma. 39% bacteria, 28% fungus, 6 % mix (bacterial + fungal) keratitis were isolated. Staphylococcus aureus (16%) was most common gram positive organism and Pseudomonas aeruginosa(16%) was the most common gram negative organism isolated in culture. For gram positive organism, vancomycin was 100% sensitive drug. 20(80%) cases of Bacterial, 17 (100%) cases of viral and 8(56%) cases of fungal keratitis improved with medical treatment. Surgical intervention required in 17(26%) cases. 43(67%) cases developed healed scar formation at the end of the treatment, 3(5%) cases developed adherent leucoma, and 4(6 %)cases underwent evisceration. Conclusion– Corneal ulcer seen in working age group, mostly.  Farmers, labourer and person with history of trauma are more prone to have corneal ulcer. Staphylococcus aureus and pseudomonas aeruginosa were most common organism. Majority patients responded to medical therapy and healed by corneal scarring.