Surgical site infection (SSI) remains one of the most important problems in infection control. SSIs increase the length of hospital stay and increase cost of care. The aim of this study is to find out the role of prophylactic antibiotics and prevalence of postoperative wound infection in surgery department.  In this prospective study, 100 cases were studied in department of surgery, from January 2016 to June 2016. All patients were clinically evaluated and thoroughly investigated.  During this period a total of 100 patients underwent major surgeries, out of which 07 cases developed post operative wound infections with rate being 07%.The rate was found to be higher among the emergency (34%) with the common risk factors being anaemia, prolonged operation and diabetes. Prophylactic Antibiotics played a major role in reducing the post–op wound infections. The common causative organism was found to be E. Coli.