Pyodermas are bacterial infections of the skin infection mostly caused by Staphylococcus aureus.. Various factors like poverty, malnutrition, overcrowding, and poor hygiene have been stated to be responsible for its higher incidence in the lower socio–economic class. Changing trends are being noted in the epidemiological aspect of pyodermas and the problem of emergence of increased drug resistant strains is being observed recently. One hundred and sixteen patients were studied to find out the pattern of pyodermas and their antibiotic sensitivity pattern in this geographic region. The most common isolated organism was S. aureus. Vancomycin,  amikacin, ceftriaxone, sulbactum, nitrofurantoin, gentamicin, and amoxyclav showed higher sensitivity as compared to cefixime, ciprofloxacin, cefuroxime, doxycyclin, erythromycin, co–trimoxazole, and amoxycillin. It would be ideal to do culture and sensitivity tests before prescribing antibiotics, but as this is not always feasible, studies should be conducted to determine the changing trends in etiological agents and antibiotic resistance.