Introduction: Premedication can reduce intra and postoperative opioid requirements without affecting hemodynamics. In this study, various doses of oral clonidine used to assess intraoperative fentanyl requirement,  postintubation mean arterial pressure, postoperatively time taken for first analgesic dose and postoperative total analgesic requirement for first 24 hours. Methods and Material: Institutional ethical committee approval and written informed consent obtained and studied for 2 years. 200 patients divided into 4 groups. Group P, C2, C3 and C4 received tablet ranitidine 150mg, oral clonidine 2µg/kg, 3µg/kg and 4µg/kg respectively 90 minutes preoperatively. Postoperatively, patients received Inj Paracetamol 1 gm i.v. if NRS score was ≥ 5. Post intubation mean arterial pressure, intraoperative bradycardia, total fentanyl used, and time taken for first request of analgesic, postoperative analgesic requirement for 24 hrs were recorded. Results: Intraop fentanyl and postoperative analgesic requirements were significantly greater in placebo group compared to clonidine group (p<0.05). Significant rise in mean arterial pressure was noted after postintubation period with prolonged time to reach baseline readings in placebo group than clonidine group (p<0.05). Low incidence of bradycardia and prolonged postoperative analgesia was observed in group C2 when compared to other clonidine groups. Conclusion: Oral clonidine (3µg/kg) premedication reduces intraoperative fentanyl and postoperative analgesic requirement.