BACKGROUND:                 Thrombocytopenia is defined as <150000/µ1 platelet count.  This  is due  to  decreased   production,   increased  destruction   (immunogenic  and  non–immunogenic),  increased  sequestration  in  spleen.  Of these infections being ·  the commonest cause of thrombocytopenia. At times the fever course is prolonged and fever with 1hrombocytopenia narrows the differential diagnosis of the clinical entity.              Septicemia :   Infections like malaria, dengue,  leptospirosis, typhoid,  HIV and  military  TB  are  some  of the  common  causes  of fever with thrombocytopenia. Therefore  a well  organized  systemic approach  that  is  carried  out  with an  awareness  of  causes  of  fever  with  thrombocytopenia  can  shorten   the duration of investigations and bring out diagnosis. Hence, a need for study to know the causes and complications of fever with thrombocytopenia     AIMS &OBJECTIVES: 1 .To evaluate clinical profile of fever with thrombocytopenia. 2. To    assess    the    clinical    complications    associated     with    fever   and thrombocytopenia.   STUDY DESIGN: Cross sectional observational study.     MEHTOD OF STUDY: The present study was undertaken between the years 2013–2015 at CAIMS (Chalmeda  Anandarao Institute of Medical Sciences Karimnagar). We prospectively collected a series of 100 patients with febrile thrombocytopenia RESULTS:             Clinical manifestation of thrombocytopenia was present only in18cases and in 88 cases it was not present.   Out of  18  cases  which  had thrombocytopenic  manifestations  petichae/  purpura was  present  in  12  cases  accounting  for  67%  and  spontaneous  bleeding  in  6 cases accounting  for 33%.  In general,88 cases  had good recovery and 12 cases  had mortality.                                                         CONCLUSIONS:    Fever with   thrombocytopenia consists   of occult presentations of common diseases rather than rare disease.