Pleural Mesothelioma is a rare neoplasm. Main risk factor is asbestos exposure. Most commonly reported symptoms include dyspnea resulting from pleural effusion and pain in the chest. 45–year–old male presented with complains of cough, dyspnea and chest pain for three weeks. No h/o smoking or exposure to asbestosis. Chest x–ray showed a shadow in the right chest caused by presence of fluid in the pleural cavity. Chest CT showed diffused homogenously enhancing plaques with pleural thickening in mass formation in entire coastal and mediastinal pleura of right hemi thorax. Then patient underwent thoracoscopy and biopsies were sampled. By microscopic imaging and immunohistochemistry, we could diagnose malignant pleural mesothelioma. Pleural Mesothelioma without asbestos and radiation exposure is rare case presentation